My research across real-world evidence, clinical AI, clinical pharmacology and evidence synthesis. Explore the finding, then follow the published source.
137 records · 2016–2026 · articles, abstracts, books & inventions
Clinical AI & real-world data
22 records · newest first
1 / 22
2026
Conference abstract
Combining EHR Signals to Recognize PAH
Key findingMachine-learning models distinguished pulmonary hypertension groups using health records; adding echocardiographic measurements improved performance over models without them.
Title & citation
A24-10 A Machine Learning Framework for Early Recognition of Pulmonary Arterial Hypertension Using Electronic Health Record Data
Study focusEvaluates potential direct medical cost savings associated with earlier pulmonary arterial hypertension detection using a machine-learning algorithm.
Title & citation
EE68 DIRECT MEDICAL COSTS SAVED BY EARLY PAH DETECTION USING A MACHINE LEARNING ALGORITHM
Study focusCompares demographic characteristics and accompanying health conditions in patients with narcolepsy and a propensity-matched comparison cohort.
Title & citation
Demographics and Comorbidities of Patients With Narcolepsy: A Propensity Score–Matched Cohort Study
Soltis, M.; Lipford, M. C.; Smither, A.; Kumar-M, P.; Gudeman, J.
Sleep Medicine 138(Supplement):107503 · 2026
This card describes the topic. An outcome summary is not available from the source reviewed.
The inventionDescribes converting published guidelines into algorithm modules and combining them with processed patient data to generate clinical outputs.
Title & citation
Apparatus and method for generating algorithm modules based on a plurality of published guidelines using machine learning
Barve, Rakesh; Anand, Akash; Kumar M, Praveen; Padhye, Chinmay
Key findingA clinical NLP workflow captured breast cancer progression with high accuracy and produced progression-free survival estimates close to manual review.
Title & citation
A Deep Learning–Enabled Workflow to Estimate Real-World Progression-Free Survival in Patients With Metastatic Breast Cancer: Study Using Deidentified Electronic Health Records
Study focusExamines whether remnant cholesterol levels are associated with major cardiovascular events in people with established atherosclerotic cardiovascular disease.
Title & citation
Real-world analysis of the association of remnant cholesterol levels with major cardiovascular events in patients with atherosclerotic cardiovascular disease
The study planDescribes a planned cluster randomized trial testing whether AI-assisted chart review and care-gap alerts improve guideline-directed heart failure prescribing.
Title & citation
A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF): Clinical trial design and methods
Lopez-Jimenez, Francisco; Alger, Heather M; Hackett, Sarah P; Gundurao, Vinay; Mehta, Ketan; Jain, Prerak; Kumar-M, Praveen; Padhye, Chinmay; Puranik, Arjun; Vassor, Kitzner; et al.
American Heart Journal Plus: Cardiology Research and Practice · 2025
Key findingAI models showed promising discrimination between intestinal tuberculosis and Crohn’s disease, but all studies were retrospective and direct comparisons with conventional models were absent.
Title & citation
Artificial intelligence for discrimination of Crohn's disease and gastrointestinal tuberculosis: A systematic review
Key findingA semi-automated text-analysis workflow captured breast-cancer progression accurately and produced progression-free-survival estimates close to manual review in a validation subset.
Title & citation
A deep learning–enabled workflow to estimate real world progression-free survival in patients with metastatic breast cancer
Key findingPatients with narcolepsy had more psychiatric, sleep, and pain disorders than matched controls, revealing a broader burden beyond narcolepsy-specific symptoms.
Title & citation
Demographic characteristics and comorbidities of patients with narcolepsy: a propensity-matched cohort study
The study planThe ACT-HF conference abstract describes a pragmatic trial evaluating clinical decision support for guideline-directed heart-failure medication management.
Title & citation
A PRAGMATIC TRIAL EVALUATING THE IMPACT OF THE ANUMANA CLINICAL DECISION SUPPORT TOOL FOR GUIDELINE-DIRECTED MEDICAL THERAPY OF HEART FAILURE (ACT-HF): STUDY DESIGN AND METHODS
The inventionThe patent describes using multiple machine-learning models to annotate unstructured electronic records and convert agreed annotations into structured data.
Title & citation
Apparatus and method for generating annotations for electronic records
Jaiswal, Shashank; Kumar, Praveen; Anand, Akash; Barve, Rakesh
Key findingMatched narcolepsy groups treated or untreated with sodium oxybate had no significant comorbidity differences after adjustment for multiple comparisons.
Title & citation
0576 Characterization of Patients With Narcolepsy Treated vs Not Treated With Sodium Oxybate: A Propensity Score–Matched Cohort Study
Key findingElectronic-record machine-learning models predicted Barrett’s esophagus and esophageal adenocarcinoma with better discrimination than conventional risk-factor scores in the study dataset.
Title & citation
Development of Electronic Health Record-Based Machine Learning Models to Predict Barrett's Esophagus and Esophageal Adenocarcinoma Risk
Iyer, Prasad G; Sachdeva, Karan; Leggett, Cadman L; Codipilly, D Chamil; Abbas, Halim; Anderson, Kevin; Kisiel, John B; Asfahan, Shahir; Awasthi, Samir; Anand, Praveen; et al.
Clinical and Translational Gastroenterology · 2023
Key findingClinical notes documented frequent sodium oxybate discontinuation and difficulty waking for the second nightly dose, with reported consequences from missed doses.
Title & citation
0584 Sodium Oxybate Treatment Patterns in Narcolepsy Patients: A Propensity Score–Matched Cohort Study Subanalysis
Key findingA plasma multiomics model predicted severe COVID-19 better than conventional cytokine markers, but lacked validation in an independent patient cohort.
Title & citation
Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study
Byeon, Seul Kee; Madugundu, Anil K; Garapati, Kishore; Ramarajan, Madan Gopal; Saraswat, Mayank; Kumar-M, Praveen; Hughes, Travis; Shah, Rameen; Patnaik, Mrinal M; Chia, Nicholas; et al.
Key findingA preprint analysis found nausea more frequently documented in women after COVID vaccination, while fever after the first dose was more common in men.
Title & citation
Female-male differences in COVID vaccine adverse events have precedence in seasonal flu shots: a potential link to sex-associated baseline gene expression patterns
Key findingThe SMART-CT index predicted several acute pancreatitis outcomes with moderate accuracy in a small retrospective development and validation study.
Title & citation
Development and validation of a computed tomography index for assessing outcomes in patients with acute pancreatitis:“SMART-CT” index
Key findingIndia’s age-standardized IBD burden remained below global levels, while incidence rose slightly and mortality and disability rates declined between 1990 and 2019.
Title & citation
Burden of inflammatory bowel disease in India: analysis of the Global Burden of Disease study from 1990 to 2019
Key findingRecords from two US health systems identified Alagille syndrome patients whose documented manifestations were predominantly hepatic, followed by cardiac abnormalities.
Title & citation
Characterization of a cohort of patients with Alagille syndrome (ALGS) from two US health systems identified leveraging natural language processing
Key findingPatients first documented with PFIC at age ten or later had varied presentations, most commonly cholestasis and itching.
Title & citation
Characterization of a cohort of patients with later-onset progressive familial intrahepatic cholestasis (PFIC) from two US health systems identified leveraging natural language processing (NLP)
Key findingElevated liver enzymes affected roughly one-fifth of celiac patients; most patients with liver abnormalities improved after a gluten-free diet.
Title & citation
Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta-analysis
Key findingPancreatitis in pregnancy was usually mild and more common later in pregnancy, but fetal complications remained an important concern across heterogeneous studies.
Title & citation
Acute pancreatitis in pregnancy and its impact on the maternal and foetal outcomes: A systematic review
Key findingGallbladder wall features and the liver interface helped distinguish benign from malignant thickening, although ultrasound findings had variable diagnostic accuracy.
Title & citation
Grayscale ultrasonography findings for characterization of gallbladder wall thickening in non-acute setting: a systematic review and meta-analysis
Key findingSplanchnic vein thrombosis was associated with infected pancreatic necrosis and bloodstream infection among patients whose necrotic collections required drainage.
Title & citation
Splanchnic Vein Thrombosis: A Harbinger of Infection in Peri/Pancreatic Necrotic Collections
Calprotectin changes during intestinal tuberculosis treatment
Key findingFalling faecal calprotectin during tuberculosis treatment helped distinguish intestinal tuberculosis from alternative diagnoses and assess response in a small prospective study.
Title & citation
Serial measurements of faecal calprotectin may discriminate intestinal tuberculosis and Crohn’s disease in patients started on antitubercular therapy
Key findingRadiofrequency, microwave, and cryoablation showed no statistically significant differences in survival or local recurrence for very early and early liver cancer.
Title & citation
Overall survival and local recurrence following RFA, MWA, and cryoablation of very early and early HCC: a systematic review and Bayesian network meta-analysis
Key findingIBD was not associated with higher SARS-CoV-2 infection risk; observational data linked steroid use to worse COVID-19 outcomes and biologics to better outcomes.
Title & citation
Risk and outcomes of coronavirus disease in patients with inflammatory bowel disease: a systematic review and meta-analysis
Key findingFever and cough were common, and gastrointestinal symptoms also occurred; COVID-19 presentations in IBD resembled those reported in the general population.
Title & citation
Clinical presentation of COVID-19 in patients with inflammatory bowel disease: a systematic review and meta-analysis
Anupam K. Singh, Anuraag Jena, Praveen Kumar-M, Daya Krishna Jha, Vishal Sharma
Interpreting Calprotectin During COVID-19 Infection
Key findingFecal calprotectin was often elevated in hospitalized COVID-19 patients, complicating its interpretation as an isolated marker of an IBD flare.
Title & citation
Fecal calprotectin levels in COVID-19: Lessons from a systematic review on its use in inflammatory bowel disease during the pandemic
Key findingLonger organ failure and sequential multiple-organ failure were associated with higher mortality in necrotizing pancreatitis; onset timing was not associated with mortality.
Title & citation
Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis
Key findingGastroduodenal tuberculosis had varied presentations; the review described biopsy-based diagnosis, antitubercular therapy, and endoscopic dilation for selected strictures.
Title & citation
Gastroduodenal tuberculosis: a case series and a management focused systematic review
Key findingAbbreviated MRI detected liver cancer more sensitively than ultrasound; contrast and noncontrast protocols performed similarly, with lower sensitivity for small tumors.
Title & citation
Abbreviated MRI for hepatocellular carcinoma screening: A systematic review and meta-analysis
Antibiotics to prevent spontaneous bacterial peritonitis
Key findingA network meta-analysis supported rifaximin for primary and secondary peritonitis prevention, while daily norfloxacin showed benefit for primary prevention.
Title & citation
Antibiotics for prophylaxis of spontaneous bacterial peritonitis: systematic review & Bayesian network meta-analysis
Key findingUltrasound, CT, and MRI showed high diagnostic accuracy for Budd Chiari syndrome, although substantial variation between studies limits certainty.
Title & citation
Diagnostic accuracy of Doppler ultrasound, CT and MRI in Budd Chiari syndrome: systematic review and meta-analysis
Key findingTreatment interruptions affected about one in ten IBD patients during early COVID-19, with regional differences and concerns about treatment safety.
Title & citation
Systematic review on failure to adhere to IBD therapies during the COVID-19 pandemic: Correct information is crucial
The perspectiveThis review explains imaging criteria and post-treatment appearances used to distinguish expected changes from residual or recurrent hepatocellular carcinoma.
Title & citation
Response assessment following image-guided therapy of hepatocellular carcinoma
The perspectiveAn imaging-based approach organizes the many causes of gallbladder wall thickening and helps distinguish suspicious patterns from benign conditions.
Title & citation
Imaging-based algorithmic approach to gallbladder wall thickening
Comparing antibiotics to prevent peritoneal infection
Study focusThis conference abstract compares antibiotic regimens for primary and secondary prevention of spontaneous bacterial peritonitis using a Bayesian network meta-analysis.
Title & citation
IDDF2019-ABS-0332 Comparison of antibiotics for the primary and secondary prophylaxis of spontaneous bacterial peritonitis: a systematic review and network meta-analysis with bayesian approach
Rethinking how peritoneal tuberculosis is classified
The perspectiveA review found overlapping peritoneal tuberculosis categories and proposed classification by dominant abdominal distension or pain and obstruction, requiring future validation.
Title & citation
Controversies in classification of peritoneal tuberculosis and a proposal for clinico-radiological classification
Study focusThis conference abstract evaluates intestinal tissue Xpert MTB/RIF testing in patients with ulcers near the junction of the small and large intestine.
Title & citation
IDDF2019-ABS-0044 Utility of intestinal tissue biopsy xpert-Mtb/Rif in evaluation of patients with ileo-caecal ulcers
Key findingLong COVID was associated with more severe acute infection and prior chronic pulmonary disease, migraine, and fibromyalgia in a matched retrospective study.
Title & citation
Case-control study on post-COVID-19 conditions reveals severe acute infection and chronic pulmonary disease as potential risk factors
COVID Vaccine Responses During Immune-Mediated Disease
Key findingAntibody responses after COVID vaccination were lower in immune-mediated inflammatory diseases, particularly with anti-CD20 or anti-CTLA-4 therapy; two-dose recipients had higher pooled responses.
Title & citation
Response to SARS-CoV-2 vaccination in immune mediated inflammatory diseases: Systematic review and meta-analysis
Jena, Anuraag; Mishra, Subhra; Deepak, Parakkal; Kumar-M, Praveen; Sharma, Aman; Patal, Yusuf I; Kennedy, Nicholas A; Kim, Alfred HJ; Sharma, Vishal; Sebastian, Shaji
Key findingHepatitis A vaccination uptake was low in inflammatory bowel disease, despite strong antibody responses after two doses; baseline seroprevalence resembled controls.
Title & citation
Systematic Review and Meta-Analysis: Seroprevalence, Vaccination Rates, and Response for Hepatitis A in Inflammatory Bowel Disease
Monitoring Hydroxychloroquine Use During Early COVID
Key findingAmong screened healthcare workers receiving hydroxychloroquine, adverse events were mild or moderate; this monitoring study did not establish prevention of COVID-19.
Title & citation
System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: Preliminary experience of a tertiary care institute in India
Key findingAfter stewardship and infection-control measures, antibiotic use and ventilator-associated pneumonia decreased; central-line bloodstream infection rates remained similar.
Title & citation
Impact of an antimicrobial stewardship and monitoring of infection control bundle in a surgical intensive care unit of a tertiary-care hospital in India
Key findingPharmacy professionals reported better attitudes but lower knowledge and practice scores than the earlier pharmacologist survey, supporting collaborative training for drug information services.
Title & citation
Drug Information Services in Low-Resource Setting: A Responsibility of Pharmacists or Pharmacologists or Both the Professions Conjointly
Amol N Patil, M Praveen Kumar, Rohitash Yadav, Sourabh Kosey, Tapan Behl, J Kumaravel
Key findingGround-glass opacities were frequent in COVID-19, but CT findings had insufficient sensitivity and specificity to serve as the primary diagnostic test.
Title & citation
Diagnostic accuracy of CT and radiographic findings for novel coronavirus 2019 pneumonia: Systematic review and meta-analysis
The perspectiveAn early-pandemic review emphasized uncertain evidence for drug prophylaxis, ongoing vaccine development, and the need to critically appraise prevention claims.
Comparing tuberculosis medicine restart strategies
Key findingSequential and gradual tuberculosis drug reintroduction showed lower estimated hepatitis risk than simultaneous restarting, but differences were not statistically significant.
Title & citation
Risk of hepatitis with various reintroduction regimens of anti-tubercular therapy: a systematic review and network meta-analysis
Key findingEarly COVID-19 reports described several skin manifestations, with rashes most prominent; pooled prevalence estimates varied widely across studies.
Title & citation
The trend of cutaneous lesions during COVID-19 pandemic: lessons from a meta-analysis and systematic review
Rajan M, Bandhala; Kumar-M, Praveen; Bhardwaj, Abhishek
Antibiotic resistance after intestinal perforation
Key findingIn a prospective local cohort, E. coli predominated in perforation-related abdominal infections, with variable antibiotic susceptibility across the cultured bacteria.
Title & citation
Antimicrobial susceptibility patterns of organisms causing secondary abdominal infections in patients with perforated abdominal viscus
Preparing pharmacologists to provide drug information
Key findingA survey of Indian pharmacology academics identified training needs in critical appraisal and in establishing and maintaining drug information services.
Title & citation
Decoding the roadmap for capacity building of pharmacology academicians in catering to drug information center services in a developing country
Restarting tuberculosis treatment after liver injury
Study focusThis conference abstract compares sequential, incremental, and simultaneous reintroduction of tuberculosis medicines after treatment-related hepatitis.
Title & citation
IDDF2019-ABS-0045 Comparison of sequential, incremental and concomitant reintroduction regimens of anti-tubercular therapy (ATT) after initial episode of ATT hepatitis: a systematic review and network meta-analysis
Growing an institutional antibiotic stewardship program
The perspectiveThis institutional report describes how a research initiative developed into a formal antimicrobial stewardship committee, including implementation challenges and future priorities.
Title & citation
Antimicrobial Stewardship Program of Postgraduate Institute of Medical Education and Research, Chandigarh: running fast to catch the missed bus
Key findingAfter stewardship implementation, a hospital unit used fewer antibiotics per patient, reduced overlapping anaerobic coverage, and increased optimized dosing.
Title & citation
Antibiotic stewardship in a tertiary care hospital of a developing country: establishment of a system and its application in a unit—GASP Initiative
Key findingA review and expert statement found encouraging cancer-control outcomes and high urinary continence after whole-gland ablation, based largely on retrospective studies.
Title & citation
Primary Whole-gland Ablation for the Treatment of Clinically Localized Prostate Cancer: A Focal Therapy Society Best Practice Statement
Deivasigamani, Sriram; Kotamarti, Srinath; Rastinehad, Ardeshir R; Salas, Rafael Sanchez; De La Rosette, JJMCH; Lepor, Herbert; Pinto, Peter; Ahmed, Hashim U; Gill, Inderbir; Klotz, Laurence; et al.
Key findingEndoscopic drainage was associated with higher clinical success and faster organ-failure resolution than percutaneous drainage in patients with walled-off pancreatic necrosis.
Title & citation
Endoscopic drainage versus percutaneous drainage for the management of infected walled-off necrosis: a comparative analysis
Endoscopic Treatment of Large Esophageal Diverticula
Key findingAll five patients improved after diverticular endoscopic myotomy, with no symptom recurrence during follow-up; two experienced minor procedural adverse events.
Title & citation
Per oral endoscopic myotomy for the management of large esophageal diverticula (D-POEM): safe and effective modality for complete septotomy
Key findingRobotic esophagectomy was associated with shorter hospitalization; operative time, blood loss, lymph-node yield, and clear-margin rates were similar to video-assisted surgery.
Title & citation
Robot-assisted versus video-assisted thoraco-laparoscopic McKeown’s esophagectomy for esophageal cancer: a propensity score-matched analysis of minimally invasive approaches
The perspectiveReviews bariatric procedures, patient selection, benefits, complications, and the need for lasting dietary follow-up and nutritional supplementation.
Title & citation
Surgical Management of Obesity: A Broad Overview of Bariatric and Metabolic Surgery
Diabetes and Outcomes After Pancreatic Cancer Surgery
Key findingPreoperative diabetes was associated with poorer long-term overall survival after pancreaticoduodenectomy, without a significant increase in postoperative complications.
Title & citation
Impact of diabetes mellitus on morbidity and survival after pancreaticoduodenectomy for malignancy
Diverticular Myotomy Across the Published Evidence
Key findingPooled studies found high success with diverticular endoscopic myotomy and better clinical success than flexible septum division, with comparable adverse-event rates.
Title & citation
Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis
Key findingEarly precut fistulotomy reduced fluoroscopy time and radiation exposure during difficult biliary cannulation, with technical success comparable to later precut.
Title & citation
A pilot randomized trial to study the success rate of early precut fistulotomy and its effect on radiation dose in patients with difficult biliary cannulation.
Key findingAcross liver tumor studies, irreversible electroporation had mostly minor complications; the review also estimated survival after treatment.
Title & citation
Efficacy and safety of irreversible electroporation for malignant liver tumors: a systematic review and meta-analysis
Abdominal pressure changes after pancreatic drainage
Key findingA larger fall in abdominal pressure after drainage was associated with better survival among acute pancreatitis patients with elevated abdominal pressure.
Title & citation
Reduction of intra-abdominal pressure after percutaneous catheter drainage of pancreatic fluid collection predicts survival
Key findingA small randomized trial found fewer superficial surgical site infections with bile duct clamping during pancreaticoduodenectomy.
Title & citation
Effect of bile duct clamping versus no clamping on surgical site infections in patients undergoing pancreaticoduodenectomy: a randomized controlled study
Key findingEndovascular embolization had high technical and clinical success for pancreatitis-related pseudoaneurysms; success did not differ significantly between acute and chronic pancreatitis.
Title & citation
Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis
Study focusThis conference abstract examines whether diabetes is associated with perioperative outcomes and survival in pancreatic and periampullary adenocarcinoma.
Title & citation
Su2049 IMPACT OF DIABETES MELLITUS ON PERIOPERATIVE OUTCOMES AND SURVIVAL IN PANCREATIC AND PERIAMPULLARY ADENOCARCINOMA
Pancreatic Stiffness Before Surgery Predicts Leaks
Key findingLower pancreatic stiffness on preoperative ultrasound was associated with clinically relevant pancreatic fistula after pancreaticoduodenectomy in a small prospective cohort.
Title & citation
Role of ultrasound shear wave elastography in preoperative prediction of pancreatic fistula after pancreaticoduodenectomy
The perspectiveThis review explains the imaging features radiologists should assess before percutaneous biliary drainage in patients with obstructive jaundice.
Title & citation
Imaging in obstructive jaundice: what a radiologist needs to know before doing a percutaneous transhepatic biliary drainage
Gupta, Pankaj; Gupta, Jyoti; Kumar-M, Praveen
Journal of Clinical Interventional Radiology ISVIR · 2020
Study focusThis conference abstract investigates predictors of catheter drainage outcomes in acute pancreatitis and describes development of a predictive model.
Title & citation
IDDF2019-ABS-0112 Predictors of outcome of percutaneous catheter drainage of acute pancreatitis with fluid collection and development of a predictive model
Predicting success after pancreatic fluid drainage
Key findingResolution of organ failure and shrinking fluid collections one week after drainage predicted successful outcomes in patients with acute pancreatitis.
Title & citation
Predictors of outcome of percutaneous catheter drainage in patients with acute pancreatitis having acute fluid collection and development of a predictive model
Key findingA retrospective cohort produced internally validated models using disease severity and treatment response to estimate failure of drainage for infected pancreatic necrosis.
Title & citation
Predrainage and Postdrainage Prognostic Nomograms to Predict Outcome of Percutaneous Drainage for Infected Pancreatic and Peripancreatic Necrotic Collections
Key findingChildren with septic shock had lower levels of five non-thiamine B vitamins than sibling controls; supplementation benefits were not tested.
Title & citation
Status of Non-Thiamine B-vitamins in Children with Septic Shock from a Lower Middle Income Country: A Case-Control study
Comparing Steroid Doses Before Pediatric Extubation
Study focusA randomized trial compared lower and higher dexamethasone doses before planned extubation in children; the accessible abstract does not report outcomes.
Title & citation
Twenty-four-hour pretreatment with low dose (0.25 mg/kg/dose) versus high dose (0.5 mg/kg/dose) dexamethasone in reducing the risk of postextubation airway obstruction in children: A randomized open-label noninferiority trial
Dexamethasone Doses Before Removing Breathing Tubes
Study focusConference trial compares higher and lower dexamethasone doses before planned extubation to prevent airway obstruction in children.
Title & citation
O035/# 470: 24-HOUR PRETREATMENT WITH HIGH DOSE (0.5 MG/KG/DOSE) VERSUS LOW DOSE (0.25 MG/KG/DOSE) DEXAMETHASONE FOR PREVENTION OF POST-EXTUBATION AIRWAY OBSTRUCTION IN CHILDREN: A RANDOMIZED OPEN-LABEL TRIAL
Baranwal, A; Parajuli, B; Kumar-M, P; Jayashree, M
Pediatric Critical Care Medicine · 2021
This card describes the topic. An outcome summary is not available from the source reviewed.
Key findingChildren with sepsis had higher ferritin and lower soluble transferrin receptor levels than controls; iron markers did not distinguish survivors from nonsurvivors.
Title & citation
Effect of Sepsis on Iron Parameters in a Population with High Prevalence of Malnutrition and Iron Deficiency: A Cross-Sectional Case–Control Pilot Study
Tracking heart dysfunction during pediatric sepsis
Key findingIn children surviving septic shock, higher CPK-MB levels declined alongside clinical improvement and recovering heart function, suggesting a possible monitoring role.
Title & citation
Longitudinal Study of CPK-MB and Echocardiographic Measures of Myocardial Dysfunction in Pediatric Sepsis: Are Patients with Shock Different from Those without?
Understanding young women’s corneal-donation views
Key findingWillingness to discuss donation with family and donation awareness were associated with better knowledge; survey analysis identified differing knowledge-and-attitude groups.
Title & citation
Perception of college-going girls towards corneal donation in North India: A latent class analysis study
The perspectiveThe authors clarify patient selection, rescue-treatment criteria, and limitations of their trial of dexamethasone implants during diabetic cataract surgery.
Title & citation
Nuances of using intraoperative dexamethasone implant in patients of diabetic retinopathy undergoing cataract surgery
Key findingDexamethasone improved macular-thickness measures after cataract surgery; differences in rescue treatment, visual acuity, and eye pressure were not statistically significant.
Title & citation
Effect of sustained-release long-acting intravitreal dexamethasone implant in patients of non-proliferative diabetic retinopathy undergoing phacoemulsification: A randomized controlled trial
The perspectiveThis early-pandemic review outlined triage, examination-room, operating-theater, and staff protocols for ophthalmology services during COVID-19.
Title & citation
Reworking protocols in the ophthalmology department during the COVID-19 crisis
Gupta, Parul Chawla; Kumar-M, Praveen; Ram, Jagat
Annals of the National Academy of Medical Sciences (India) · 2020
Study focusThis conference study evaluated an intravitreal dexamethasone implant during cataract surgery in patients with nonproliferative diabetic retinopathy.
Title & citation
ASCRS2020-ABS-The Effect of Intravitreal Dexamethasone Implant in Patients with Non-Proliferative Diabetic Retinopathy Undergoing Phacoemulsification
The perspectiveThis early-pandemic review described ocular presentations of COVID-19 and approaches to examination precautions, urgent eye care, and remote consultations.
Title & citation
COVID-19 pandemic from an ophthalmology point of view
Study focusConference presentation on estimating congenital rubella probability from eye findings using a sentinel-surveillance nomogram.
Title & citation
ASCRS2020-ABS-Nomogram for the Prediction of Probability of Rubella Based on Eye Outcomes (PRBEO Nomogram)-a Cross Sectional Sentinel Surveillance Study
Comparing Asparaginase Formulations in Childhood Leukemia
Key findingPegylated biosimilar asparaginase produced higher day-33 activity and fewer subtherapeutic levels than native asparaginase in a small randomized childhood leukemia trial.
Title & citation
Comparative assessment of asparaginase activity, population pharmacokinetics, and safety of biosimilar native Escherichia coli and pegylated asparaginase in children with newly diagnosed acute lymphoblastic leukemia: a pharmacometrics-based randomized clinical trial
Key findingMatched narcolepsy cohorts had no statistically significant comorbidity differences; chart review identified treatment discontinuation and difficulty waking for the second nightly sodium oxybate dose.
Title & citation
Characterization and treatment patterns of patients treated with immediate-release sodium oxybate for narcolepsy: A propensity score–matched cohort study
Key findingIn South Asian studies, NUDT15 variants were more common than TPMT variants and more strongly associated with thiopurine adverse events.
Title & citation
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis
Key findingQT prolongation was common among COVID-19 patients receiving hydroxychloroquine or chloroquine; torsades was uncommon, and adding azithromycin showed no statistically significant increase.
Title & citation
Hydroxychloroquine and QTc prolongation in patients with COVID-19: a systematic review and meta-analysis
Key findingThe antenatal survey found nonprescription antimicrobial use and frequent reliance on local chemists, highlighting gaps in medication knowledge and practices.
Title & citation
Identification of At-risk Pregnant Population for Over-the-Counter Drug Usage in Low-Resource Settings
Key findingAmong hospital-treated poisoning cases in India, pesticides predominated in adults, while miscellaneous agents were the largest category in children.
Title & citation
Toxicoepidemiology of poisoning exhibited in Indian population from 2010 to 2020: a systematic review and meta-analysis
Key findingTriamcinolone injections improved patchy hair regrowth versus saline, but the highest concentration caused more local adverse effects, supporting a cautious step-up approach.
Title & citation
Identification of novel step-up regimen of intralesional triamcinolone acetonide in scalp alopecia areata based on a double-blind randomized controlled trial
Key findingBrain phenytoin concentrations were lower after severe aneurysmal subarachnoid hemorrhage, while plasma and cerebrospinal fluid concentrations did not differ significantly.
Title & citation
Aneurysmal subarachnoid hemorrhage: Impact on phenytoin permeability across the blood–brain barrier
Preventing Liver Injury During Tuberculosis Treatment
Key findingN-acetylcysteine showed a possible preventive benefit for tuberculosis drug-related liver injury; silymarin did not, and limited evidence left the best strategy uncertain.
Title & citation
Appropriate chemopreventive strategy for anti-tubercular therapy related liver injury is unsettled: results from a systematic review and network meta-analysis
Key findingA dermatology survey identified distinct groups using nonprescription topical medicines, including a subgroup with poorer knowledge and attitudes toward safe use.
Title & citation
Developing a latent class analysis model to identify at-risk populations among people using medicine without prescription
Computational candidates against resistant Klebsiella
Key findingComputational screening identified candidate enzyme inhibitors against resistant Klebsiella; one compound showed stable simulated binding to both targeted carbapenemases.
Title & citation
Discovery of dual inhibitors of KPC-3 and KPC-15 of Klebsiella pneumoniae – an in-silico molecular docking and dynamics study
Predicting tacrolimus dosing before kidney transplantation
Study focusThis study examines whether tacrolimus concentration two hours after dosing before transplantation predicts dosing needs after kidney transplantation.
Title & citation
Is the pretransplant C2 an optimum predictor of posttransplant dose for tacrolimus in renal transplantation patients?
The perspectiveAn academic team describes administrative obstacles encountered while importing a preclinical drug and proposes clearer import procedures for research institutions.
Title & citation
Experience of an academic institute in importing a novel preclinical drug into India
Key findingMendelian randomization linked genetic susceptibility to multiple sclerosis with Alzheimer’s risk, with pathway analyses pointing to shared T-cell biology.
Title & citation
Multiple sclerosis as a genetic risk factor for Alzheimer’s disease: Insights from Mendelian randomisation
Rajavoor Muniswamy, Jai Kumar; Reshi, Amrutha; Roy Chowdhury, Dibyendu; Kumar-M, Praveen
Inside the bookA practical introduction to R for medical research, covering data handling, statistical tests, visualizations, sample sizes, and clinical trial randomization.
Inside the bookDemonstrates common randomization methods in R, including generating, saving, and visually checking allocation sequences for reproducibility.
Title & citation
Conducting Randomization in Clinical Trials
Kumar-M, Praveen; Mishra, Archana
R for Basic Biostatistics in Medical Research · 2024
Inside the bookGuides researchers through nonparametric tests in R, connecting assumptions, clinical examples, calculations, visualizations, and interpretation.
Title & citation
Inferential Statistics for the Hypothesis Testing of Non-parametric Data
Kumar-M, Praveen; Mishra, Archana
R for Basic Biostatistics in Medical Research · 2024
Unanswered questions about pancreatic tuberculosis
The perspectiveThis letter critiques omissions in a pancreatic tuberculosis review and highlights unresolved questions about diagnosis, treatment duration, and monitoring response.
Title & citation
Systematic review on pancreatic tuberculosis: More questions
Key findingThe team built an open-source R Shiny server to calculate, store, evaluate, and interpret chromatography results for therapeutic drug monitoring.
Title & citation
WCP-2018-ABS: Shyam's Chromatography and TDM server in R shiny-an open source program for TDM laboratories
2026
